产品描述
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 应用 | A postitive allosteric modulator of mGluR-4 |
| 产品介绍 | VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. |
| 备注 | VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. |
| 生化机理 | VU 0364770 is a positive allosteric modulator of mGluR-4 (EC50 = 290 nM in mGluR-4-expressing HEK 293 cells). VU 0364770 acts in many other ways such as the reversal of haloperidol-induced catalepsy in rats; and in rodent models of Parkinson's disease, preventing attentional deficit and forelimb asymmetry. |
| 别名 | N-(3-氯苯基)-2-吡啶甲酰胺;N-(3-Chlorophenyl)-2-pyridinecarboxamide |
