产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | a selective positive allosteric modulator at mGluR-4 |
| 产品介绍 | VU 0361737是一种选择性mGlu4受体正变构调节剂 (PAM), 作用于人类和大鼠受体, EC50分别为240 nM和110 nM, 对mGlu5和mGlu8受体具有微弱的作用活性, |
| 生化机理 | VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGluR-1, mGluR-2, mGluR-3, mGluR-6 and mGluR-7 receptors and displays weak activity at mGluR-5 and mGluR-8 receptors. Also a brain penetrant. |
| 别名 | ML-128; VU-0361737; VU 0361737; N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺;;CID-44191096; ML128 ;N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide |
