产品描述
| 溶解性 | DMSO 15 mg/mL Ethanol 5 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | ARN-509是竞争性雄激素受体抑制剂，IC50为16 nM，可作用于前列腺癌。 |
| 生化机理 |
ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. |
| 别名 | ARN 509; ARN509;ARN 509; ARN509;4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-n-methylbenzamide |
