产品描述
| 沸点 | 319.64 °C/760 mmHg |
| 熔点 | 50.5-52.5 °C |
| 折光率 | 1.52 |
| 溶解性 | Soluble in methanol, 0.1 M NaOH, dichloromethane, and ethyl acetate. |
| 密度 | 1.0300 |
| 应用 | An inhibitor of Cox-1 and Cox-2. |
| 产品介绍 | (R)-Ibuprofen是ibuprofen的低活性对映体。 |
| 生化机理 | (R)-Ibuprofen, a nonsteroidal antiinflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2. Most of the activity resides in (S)-ibuprofen. It has been observed that the inversion of R(-)-ibuprofen to the S(+) antipode occurs in rat liver but not in either serosal or mucosal sides of the small intestine. (R)-Ibuprofen’s presence can be detected in urine through mass chromatography. A liquid-chromatographic assay has been used to study the pharmacokinetics of the (S)- and (R)-Ibuprofen forms in plasma. |
| 别名 | (R)-布洛芬;(R)-Ibuprofen;L-Ibuprofen;(alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid; R-(-)-p-Isobutylhydratropic acid; R-(-)-p-Isobutylhydratropic acid |
