产品描述
| 熔点 | 118-120°C |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 应用 | A dopamine (D2) and serotonin (5HT2) receptor antagonist |
| 产品介绍 | Iloperidone (伊潘立酮; HP 873) 是D2/5-HT2受体拮抗剂，可作用于精神分裂症。 |
| 生化机理 | Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug’s efficacy on mood and cognition. |
| 别名 | 伊潘立酮;Fanapt;HP 873;Zomaril;1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone |
