产品描述
| 沸点 | 650.65° C |
| 熔点 | 221-223° C |
| 折光率 | 1.65 |
| 溶解性 |
|
| 密度 | 1.3300 |
| 应用 | A potent and selective TRPA1 inhibitor |
| 产品介绍 | HC-030031是TRPA1通道阻断剂，能拮抗AITC和福尔马林诱发的钙流，IC50分别为6.2 μM和5.3 μM。 |
| 生化机理 | HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 μM respectively. Both inward and outward currents elicited by AITC or formalin are rapidly and reversibly blocked by HC-030031 which also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins2. TRPV1, TRPV3, TRPV4, hERG and NaV1.2 are not blocked. |
| 别名 | HC 030031；HC030031； 1,2,3,6-四氢-1,3-二甲基-N-(4-(1-甲基乙基)苯基)-2,6-二氧代-7H-嘌呤-7-乙酰胺;;HC 030031；HC030031； 1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide ；2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide |
