产品描述
| 溶解性 | Soluble in ethanol (5 mg/ml at 25 °C), methanol, DMF, DMSO (49 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A macrolide antibiotic with immunosuppresive activity. |
| 产品介绍 | Elaiophylin大环内脂类抗菌素，作用于恶性疟原虫K1a 和布氏布锥虫GUTat 3.1 品系，具有抗原生动物活性，IC50分别为370 ng/mL和460 ng/mL。 |
| 备注 | Elaiophylin shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, respectively. |
| 生化机理 | Elaiophylin is a highly characteristic macrolide antibiotic that was first isolated from a culture of Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity when combined with metabolite rapamycin. Elaiophylin shows shown cytotoxicity against mammalian tumor cells, protozoa, nematodes and antibacterial activity aganst gram-positive bacteria. The compound has also displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin has been found to have antihelminthic to inhibit nitric oxide synthesis. Elaiophylin is an inhibitor of 5 α-Reductase and NOS. |
| 别名 | 洋橄榄叶素;Azalomycin-B; Gopalamicin; Salbomycin; |
