产品描述
| 敏感性 | 对热敏感 |
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | Tigecycline 是一种广谱的甘氨酰环素抗生素,对 E. coli (MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/ mL。对 Acinetobacter baumannii (A. baumannii) 的 MIC50 和 MIC90 分别为 1 和 2 mg/L。 |
| 产品介绍 | Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic. It inhibits protein synthesis through the binding of the 30S ribosomal subunit of bacteria. This blocks entry of Aminoacyl-tRNA into the A site of the ribosome during translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins. |
| 备注 | Tigecycline is a glycylcycline antibiotic. |
| 生化机理 | Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. |
| 别名 | 替加环素;(4S,4aS,5aR,12aS)-4,7-双(二甲氨基)-9-[(叔丁基氨基)乙酰胺基]-3,10,12,12a-四羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺;9-叔丁基甘氨酰氨基米诺环素 ;9-t-Butylglycylamido-minocycline; TBG-MINO; Tigecyclin; Tygacil;(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;9-tert-Butylglycylamidominocycline |
