产品描述
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole，是神经保护剂，是弱的非麦角类多巴胺受体激动剂。 |
| 生化机理 |
Dexpramipexole, also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. Dexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity. |
| 别名 | KNS-760704;(R)-普拉克索;(R)-Pramipexole;R-(+)-Pramipexole;KNS-760704 |
