产品描述
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Darapladib (SB-480848)是不可逆的lipoprotein-associated phospholipase A2 (Lp-PLA2)抑制剂，其IC50为0.25 nM。 |
| 生化机理 |
Darapladib, is a novel inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme that may link lipid metabolism with inflammation, leading to the increased stability of atherosclerotic plaques present in the major arteries. Darapladib is being studied as a possible add-on treatment for atherosclerosis. |
| 别名 | SB-480848;SB480848;SB 480848;N-[2-(二乙氨基)乙基]-N-[4'-(三氟甲基)-1,1'-联苯-4-甲基]-2-[2-(4-氟苄硫基)-4-氧代-4,5,6,7-四氢-1H-环戊并[d]嘧啶-1-基]乙酰胺;SB-480848;SB480848;SB 480848;N-[2-(Diethylamino)ethyl]-N-[4'-(trifluoromethyl)-1,1'-biphenyl-4-ylmethyl]-2-[2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl]acetamide |
