产品描述
| 熔点 | 120-122 °C |
| 溶解性 | Soluble in water (partly), 1eq. NaOH (100 mM), methanol (50 mg/ml), chloroform, and ethanol. |
| 应用 | A hypolipidemic compound |
| 产品介绍 | Clofibric acid 是PPARα激动剂，是一种降血脂剂。 |
| 生化机理 | Clofibric acid is a compound that reduces cholesterol levels in blood through diminishing the activity of NADPH. In vitro experiments have demonstrated that its mode of action is to competitively inhibit NADPH by effecting the rate of substrate synthesis and substrate affinity. The compounds effects are also attributed to activation of PPARα and weak activation of both PPARγ and PPARδ. |
| 别名 | 对氯苯氧异丁酸;4-氯苯氧异丁酸;4-氯苯氧基-α-甲基丙酸;α-(对氯-2-甲基苯氧基)丙酸;PCIB;2-(4-氯苯氧基)-2-甲基丙酸;氯贝酸;降固醇酸;PCIB;Clofibric Acid;4-Chlorophenoxy iso-butyric acid;2-(p-Chlorophenoxy)-2-methylpropionic acid |
