产品描述
| 溶解性 | Soluble in ethanol (~50 mg/ml), methanol, DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~300 ug/ml). |
| 存贮条件 | 储存温度-20°C |
| 应用 | The precursor to a potent PGF2αR agonist. |
| 产品介绍 | Bimatoprost是一种前列腺素类似物，局部（眼药水）用药，治疗青光眼和高眼压症。 |
| 备注 | Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. |
| 生化机理 | Bimatoprost is converted by an amidase enzymatic activity in bovine and human cornea models to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. |
| 别名 | 比马前列素; (Z)-7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-5-苯基戊-1-烯基]环戊基]-N-乙基庚-5-烯酰胺;Lumigan;17-Phenyl-tri-norprostaglandin F2α-ethyl amide;AGN 192024; Latisse; Prostamide |
