产品描述
| 熔点 | 166.2-168.2 °C |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO (>10 mg/ml), water (<1 mg/ml), and ethanol (<1 mg/ml). |
| 存贮条件 | 储存温度2-8°C |
| 应用 | An inhibitor of angiogenesis and the release of histamine and prostaglandins. |
| 产品介绍 | Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
| 备注 | Tranilast is an antiallergic compound. |
| 生化机理 | Tranilast is an angiogenesis inhibitor that also inhibits the release of histamine and prostaglandins from basophils and mast cells. Other functions of Tranilast include the ability to inhibit leukotrienes, oxygen radicals, cyclooxygenase-2 expression, cytokines, collagen synthesis, and blocks the production of IL-1 and IL-2 from human T-cells and macrophages. Studies indicate that Tranilast blocks vascular inflammation and disrupts the NF-κB/CBP interaction, which leads to the inhibition of NF-κB dependent transcription activation. Additionally, Tranilast has been reported to inhibit the release of PGE2 and TGF-β from monocytes-macrophages and the transformation of fibroblasts to myofibroblasts, and contraction in vitro. Smooth muscle cell studies have revealed that Tranilast inhibits vascular smooth muscle cell growth, calcium entry, and acts as an antagonist of Angiotensin (angiotensin II). |
| 别名 | 曲尼司特;N-(3,4-二甲氧基肉桂酰)氨茴酸;2-[[3-(3,4-二甲氧基苯基)-1-氧-2-丙烯基]氨基]苯甲酸;N-3,4-二甲基氧基肉桂酰-邻氨基苯甲酸;N-(3,4-Dimethoxycinnamoyl)anthranilic Acid;2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid;MK 341; Rizaben; Tranpro; SB 252218 ;3,4-DAA |
