产品描述
| 熔点 | 199-203℃ |
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in water (0.4 mg/ml), ethanol (2.6 mg/ml at 20 °C), methanol (12.1 mg/ml), chloroform (22.2 mg/ml at 20 °C), and DMSO (50 mg/ml). |
| 存贮条件 | 储存温度 2-8°C ,充氩储存 |
| 应用 | An antibacterial agent which selectively inhibits dihydrofolate reductase. |
| 产品介绍 | Trimethoprim 是一种抑制细菌的抗生素，主要用于预防和治疗尿路感染 |
| 生化机理 | Trimethoprim is an antibacterial agent which selectively inhibits DHFR(dihydrofolate reductase) in prokaryotic microorganisms. in addition, trimethoprim is often combined with sulfamethoxazole to inhibit the growth of Staphylococcus aureus. Studies suggest that electro-oxidation of trimethoprim is pH dependent and irreversible. Alternate studies show that trimethoprim can synergize with oxygen causing an increase in oxygen tensions in vitro, which decreases the minimal inhibitory concentrations of trimethoprim resulting in bactericidal effects. |
| 别名 | 甲氧苄啶;2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶;甲氧苄氨嘧啶; 5-[(3,4,5-三甲氧基苯基)-甲基]-2,4-嘧啶二胺;2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine;Trimpex; Proloprim |
