产品描述
| 熔点 | 134°C |
| 敏感性 | 对湿度和空气敏感 |
| 溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol. |
| 存贮条件 | 储存温度 2-8°C ,充氩储存 |
| 应用 | A HMGCR inhibitor and anti-proliferative agent. |
| 生化机理 | Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 μM). |
| 别名 | 塞瓦停;舒降脂;西伐斯汀;辛伐他汀; (1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-六氢-3,7-二甲基-8-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-基]乙基]-1-萘酚 2,2-二甲基丁酸酯;MK 733; Simlup; Simcard; Simvacor; Simvoget; Zorced; Zocor;(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate |
