产品描述
| 存贮条件 | 储存温度2-8°C |
| 应用 | A polyether potassium ionophore. |
| 产品介绍 | Salinomycin是一种抗肿瘤抗生素，对癌症干细胞具有选择性抑制作用。 |
| 生化机理 | Salinomycin is a polyether potassium ionophore antibiotic, which promotes cation movement across biological membranes via exchange-diffusion. As a result of this cation exchange, the transmembrane gradients are altered, which leads to changes in cellular function and metabolism. In addition, Salinomycin acts as a chelating agent towards monovalent cations such as sodium and potassium ions. Alternate studies suggest that Salinomycin selectively inhibits cancer stem-like cells. |
| 别名 | 盐霉素;沙利霉素;Procoxacin;(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid |
