产品描述
| 溶解性 | DMSO: soluble7 mg/mL;H2O: insoluble |
| 存贮条件 | 储存温度 2-8°C |
| 产品介绍 | Reversine是合成的嘌呤类似物，能抑制Aurora A/B/C，IC50为150到500 nM。 |
| 生化机理 | Reversine is a cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Reversine is shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 μM. Reversine is also the first organic molecule that has been demonstrated to reverse the cellular differentiation process. The compound acts as a selective A3 adenosine receptor antagonist (Ki= 660 nM, >10 μM, and >10 μM for hA3, hA1, and hA2A, respectively. Reversine functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). The compound also acts as an ATP-competitive, reversible and selective inhibitor of ARK-1, ARK-2, and ARK-3 (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel. |
| 别名 | ;N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine;2-(4-Morpholinoanilino)-6-cyclohexylaminopurine |
