产品描述
| 溶解性 | Soluble in water (1 mg/ml at 25 °C), ethanol (62 mg/ml at 25 °C), methanol, DMSO (62 mg/ml at 25 °C), and DMF (25 mg/ml). |
| 应用 | An inhibitor of Cox. |
| 产品介绍 | Phenylbutazone 是一种非甾体抗炎剂，用于治疗慢性疼痛，包括关节炎的症状。 |
| 备注 | Phenylbutazone(Butazolidin, Butatron) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. |
| 生化机理 | Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox. |
| 别名 | 4-丁基-1,2-二苯基-3,5-吡唑烷二酮;保泰松;布他唑立丁;苯基丁氮酮;4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-Diphenyl-3,5-dioxo-4-n-butylpyrazoline |
