产品描述
| 熔点 | 365-366.8 °C |
| 溶解性 | Soluble in water (3 mg/ml), and DMSO (30 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An antagonist of muscarinic receptors. |
| 产品介绍 | Pizotifen Malate用于治疗用于经常性偏头痛。 |
| 备注 | Pizotifen Malate is a benzocycloheptane based agent used for recurrent migraine headaches. |
| 生化机理 | Pizotifen malate, a derivative of benzocycloheptathiophene, is a tricyclic compound found to be a potent inhibitor of SR-2 receptor activity. In addition, it has been found to display vasoconstrictor activity in vivo. Studies on mice suggest that Pizotifen malate may have embryotoxic effects due to decreased value of mitotic indices in bone marrow cells. Pizotifen malate has also been reported to have acute antagonistic affects on central muscarinic receptors. |
| 别名 | 苯噻啶苹果酸盐; 9,10-二氢-4-(1-甲基哌啶-4-亚基)-4H-苯并[4,5]环庚烷并[1,2-b]噻吩苹果酸盐 (1:1);Pizotyline malate; Pizotifan; BC105;9,10-Dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene malate (1:1) |
