产品描述
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 |
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of pulmonary arteries. PRX-08066 significantly reduced peak PA pressure at 50 and 100 mg/kg (P < 0.05 and < 0.01, respectively) compared with MCT control animals. The 5-HT2BR antagonist PRX-08066 significantly attenuated the elevation in PA pressure and RV hypertrophy and maintained cardiac function. PRX-08066 prevents the severity of PAH in the MCT rat model. |
