产品描述
| 沸点 | ~386.6 °C at 760 mmHg |
| 熔点 | 197.05 °C |
| 折光率 | 1.76 |
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
| 应用 | An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1 |
| 产品介绍 | OAC1是转录因子Oct4活化剂，提高iPSC的重编程效率和编程过程中的加速。 |
| 备注 | OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming. |
| 生化机理 | OAC-1 is an Oct-4 activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself). OAC-1 upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1. It has shown no effects, however, on the p53-p21 pathway or Wnt-β-catenin signaling. |
| 别名 | OAC-1；Oct4-activating Compound 1；N-1H-吡咯并[2,3-c]吡啶-5-基苯甲酰胺;OAC-1；Oct4-activating Compound 1；N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide |
