产品描述
| 熔点 | 281-283 °C |
| 溶解性 | Soluble in water (practically insoluble), chloroform (practically insoluble), ethyl ether (0.01g/>100ml) (practically insoluble), Methanol (0.01g/100ml) (very slightly soluble), 1 N Sodium hydroxide (1.0g/30ml), and DMSO. |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An inhibitor of STAT activation and signaling activity |
| 生化机理 | Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation. |
| 别名 | 硝呋齐特;硝呋酚酰肼;4-羟基-2'-(5-硝基呋喃甲叉)-苯酰肼;5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone;p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide |
