产品描述
| 溶解性 | Soluble in water (34 mg/ml at 25 °C), DMSO (34 mg/ml at 25 °C), and ethanol (34 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 -20°C |
| 应用 | A compound which inhibits burst firing without affecting normal neuronal excitability |
| 产品介绍 | Levetiracetam is an antiepileptic which displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na+-dependent Cl-/HCO3- exchange. |
| 备注 | Levetiracetam is an antiepileptic compound. |
| 生化机理 | Levetiracetam is a pyrrolidine with antiepileptic activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity. |
| 别名 | 左乙拉西坦;Keppra, Keppra XR;(S)-2-(2-oxopyrrolidin-1-yl)butanamide |
