产品描述
| 溶解性 | Soluble in chloroform, methanol, ethanol (59 mg/ml at 25 °C), DMSO (59 mg/ml at 25 °C), and DMF (~14 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition. |
| 备注 | Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. |
| 生化机理 |
Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Anastrozole reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active. |
| 别名 | 阿那曲唑;ICI-D1033;2;2"-[5-(1H-1;2;4-Triazol-1-ylmethyl)-1 3-Phenylene]bis(2-methyl-propiononitrile、 Arimidex;ZD1033 a,a,a′,a′-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile |
