产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | A potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death |
| 产品介绍 | GSK2334470是PDK1抑制剂，IC50为10 nM，对别的相关AGC激酶无活性。 |
| 生化机理 | GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). GSK2334470 can be used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt. |
| 别名 | GSK 2334470;GSK-2334470;GSK 2334470;GSK-2334470;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide |
