产品描述
| 溶解性 |
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| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | GSK690693 |
| 备注 | GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1. |
| 生化机理 |
GSK-690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). GSK-690693 also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). GSK-690693 displays antiproliferative and apoptotic effects in tumor cell lines. |
| 别名 | 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-((S)-piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol;4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-((S)-piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol |
