产品描述
| 溶解性 | Soluble in DMSO (~20 mg/ml), 100% ethanol (10 mg/ml), DMF (~20 mg/ml), and 1:1 solution of DMSO:PBS, pH 7.4 (0.5 mg/ml). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A selective PI 3-kinase p110γ inhibitor. |
| 产品介绍 | AS-252424是一种新型，有效的PI3Kγ抑制剂，IC50为30 nM，作用于PI3Kγ比作用于PI3Kα选择性高30倍，对PI3Kδ/β具有低的抑制活性。 |
| 备注 | AS-252424 is a novel, potent PI3Kγ inhibitor with IC50 of 30 nM with 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β. |
| 生化机理 | AS-252424 is a potent and selective PI 3-kinase p110γ inhibitor (IC50 = 33 nM) shown to be selective for class IB PI 3-kinase-mediated cellular effects. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 μM. AS-252424 is an inhibitor of Casein Kinase and PI 3-kinase p110 α. |
| 别名 | AS 252424; 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮;5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;AS 252424 |
