产品描述
| 溶解性 | DMSO 0.01 mg/mL (<1 mM); Water 0.01 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM) |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | LDN-193189是一种选择性的BMP信号通路抑制剂，抑制BMP I型受体ALK2和ALK3的转录活性，IC50分别为5 nM和30 nM，作用于BMP比作用于TGF-β选择性高200倍。 |
| 备注 | LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. |
| 生化机理 |
LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors. |
| 别名 | 4-[6-(4-(哌嗪-1-基)苯基]吡唑并[1,5-a]嘧啶-3-基)喹啉;LDN 193189; LDN-193189; DM-3189; DM 3189;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
