产品描述
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.1230 |
| 应用 | An inhibitor of sphingolipid biosynthesis with immunosuppressive properties. |
| 产品介绍 | Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model. |
| 生化机理 | Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. |
| 别名 | Myriocin;嗜热菌杀酵母素;ISP-1;2S,3R,4R,6E-2-氨基-3,4-二羟基-2-羟甲基L-14-氧-6-二十烯酸;(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; ISP-I; Thermozymocidin |
