熔点 | 146-147°C |
旋光率 | 46.5 ° (C=1, H2O) |
溶解性 | Soluble in water. |
存贮条件 | 储存温度2-8℃ |
密度 | 1.5330 |
应用 | 2-脱氧-D-葡萄糖(2-Deoxy-D-Glucose,2-DG)为天然抗代谢物类抗生素,具有能够抑制病毒感染、酵母发酵、致病菌及肿瘤细胞生长等。 |
产品介绍 | 溶于水和乙醇。 |
生化机理 | 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK |
别名 | 2-去氧-D-葡萄糖;2-脱氧-D-葡糖;2-Deoxy-D-arabinohexose;2-Deoxyglucose |