产品描述
| 熔点 | 251°C |
| 旋光率 | -110.5° (C=0.6,CHCl3) |
| 溶解性 | Soluble in DMSO (30 mg/ml), dimethyl formamide, ethyl ether, chloroform:methanol (1:1), methanol (slightly), acetone (slightly), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C |
| 应用 |
Inhibits DNA synthesis via topoisomerase II inhibition Etoposide has been used: · to prepare drug stock solution in dimethyl sulfoxide (DMSO) and also to profile and compare the sensitivity of DT40 mutant cells · to incubate cells for cell viability assay · to treat neuro-2A cells to induce programmed cell death |
| 产品介绍 | 依托泊苷是一种抗肿瘤剂，它与拓扑异构酶Ⅱ及DNA结合成复合物，以增强双链和单链DNA的裂解，并可逆地抑制再连接。在细胞周期S期和G2期阻断细胞周期，在正常和肿瘤细胞系中诱导细胞凋亡，抑制癌蛋白Mdm2的合成，在过渡表达Mdm2的肿瘤细胞系中诱发细胞凋亡。 |
| 生化机理 | Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2. |
| 别名 | 4'-去甲表鬼臼9 -（4,6-O-亚乙基-β-e-吡喃葡萄糖苷）VP-16-213;依托泊苷;4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside) |
