产品描述
| 熔点 | 72-75°C |
| 敏感性 | 对空气敏感 |
| 溶解性 | 溶于DMSO (10 mg/ml), 氯仿 (50 mg/ml), 和水(20 mg/ml). |
| 存贮条件 | 储存温度 -20°C，充氩保存 |
| 密度 | 0.9900 |
| 应用 | 一种Cox-2抑制剂。 |
| 产品介绍 | N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g). |
| 别名 | N-叔丁基苯硝酮;N-苯亚甲基叔丁胺-N-氧化物;叔丁基(亚苄基)胺 N-氧化物;PBN;N-Benzylidene-tert-butylamine N-oxide; PBN; Phenyl N-t-butylnitrone; Phenyl N-tert-butylnitrone; |
