产品描述
| 存贮条件 | 储存温度 -20°C |
| 应用 | An activator of multiple PKC isotypes |
| 产品介绍 | Phosphatidic Acid, Dioleoyl has been shown to activate PKC α, ε, or ζ isotypes in the cytosol of COS cells. This compound not only stimulates PKC-ζ-mediated phosphorylation of distinctive substrates, but additionally causes an upward shift in electrophoretic mobility of PKC &zeta. Furthermore, experiments have reported Phosphatidic Acid to be generated by hydrolysis of phosphatidylcholine, via phospholipase D (PLD). Mechanistic studies suggest activation of PLD by insulin and consequential generation of Phosphatidic Acid which then induces Raf-1 translocation to cell membranes. Raf-1 is an essential component to the mitogen-activated protein kinase cascade, and once it has crossed over to the plasma membrane, other factors may activate it through phosphorylation. |
| 别名 | 18:1 PA;1,2-二[顺式-9-十八碳烯酰基]-Sn-甘油-3-磷酸酯钠盐;18:1 PA;1,2-Di(cis-9-octadecenoyl)-sn-glycerol 3-phosphate sodium salt;L-α-Phosphatidic acid, dioleoyl sodium salt |
