产品描述
| 溶解性 | Soluble in chloroform. Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 应用 | An oxysterol with cholesterol oxidation metabolite properties. |
| 产品介绍 | 27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol has also been reported to increase levels of Aβ peptide production, reduce mitochondrial membrane potential, and induce nuclear factor κB (NFκB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is an activator of LXR α and LXR β. |
| 别名 | 27-羟基胆固醇;5,25R-胆甾烯-3beta,26-二醇；;27-hydroxycholesterol;5,25R-Cholesten-3beta,26-diol;cholest-5-ene-3β,27-diol, (25R);27-hydroxycholesterol(25R);(25R)-Cholest-5-ene-3β,26-diol |
