溶解性 | 易溶于氯仿,溶于甲醇、乙醇,微溶于水 |
存贮条件 | 储存温度2-8℃ |
密度 | 1.2000 |
应用 | 石杉碱甲不仅通过抑制胆碱酯酶活性,还可以通过影响自由基系统,降低生长抑素、细胞内[Ca2+]、谷氨酸含量,提高钙调蛋白(CaM)和钙调蛋白的信使核糖核酸(CaM mRNA)表达水平等多种药理机制,提高认知功能和学习记忆能力。 |
生化机理 |
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. |
别名 | (-)-石杉碱甲;(-)-Selagine |