产品描述
| 熔点 | 277-280°C |
| 溶解性 | Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM). |
| 应用 |
一个具有抗菌，消炎，抗氧化性能的天然产物。有抑制肿瘤细胞株扩增和促凋亡作用。 A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor |
| 产品介绍 | Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2. Isolated from the leaves and stems of Macleaya cordata and M. microcarpa. |
| 备注 | CAS Number: 5578-73-4 (anhydrous),Formula weight and CAS # are for anhydrous basis. |
| 别名 | 氯化血根碱;血根碱盐酸盐 |
