产品描述
| 熔点 | 84-85°C |
| 旋光率 | +103 to +112 deg(C=0.5, EtOH) |
| 敏感性 | 对光&空气&热敏感 |
| 溶解性 | Soluble in ethanol and methanol. Slightly soluble in vegetable oils. Insoluble in water. |
| 存贮条件 | 充氩保存;储存温度-20°C; |
| 密度 | 0.9600 |
| 应用 | Vitamin D3 通过受体起作用，该受体是具配体依赖性转录因子大家庭的一员，调控正常细胞和癌细胞的增殖和分化，对乳腺癌、结肠癌和前列腺癌具抗增殖、抗转移效果。肠和骨骼内激活的Vitamin D受体还能维持钙吸收和内平衡。 |
| 产品介绍 | 通常维生素D3比维生素D2稳定。D3存在于人和大多数动物组织中，在鱼肝油、肝、鱼子、乳汁、奶油和蛋黄等食物中含D3量丰富。人体皮肤内含有维生素D3的前体7-脱氢胆固醇，经日光或紫外线照射，可转变为D3，故多晒太阳可防止维生素D缺乏。 水溶性: <0.1 g/L (20°C) 溶于大多数有机溶剂，微溶于植物油。 |
| 生化机理 |
Cholecalciferol is a naturally occuring form of vitamin D. Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis. |
| 别名 | 胆骨化醇;活化7-去氢胆固醇;9,10-开环胆甾-5,7,10(19)-三烯-3beta-醇;胆钙化醇;活化7-脱氢胆甾醇;;(+)-Vitamin D3; 7-Dehydrocholesterol activated; Activated 7-dehydrocholesterol; Calciol; Cholecalciferol; 9,10-Secocholesta-5,7,10(19)-trien-3beta-ol |
