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CAS No. : 74252-25-8
MCE 国际站:Indomethacin sodium hydrate
产品活性:Indomethacin (Indometacin) sodium hydrateis 是一种有效的口服活性 COX1/2 抑制剂,COX-1 和 COX-2 的IC50 值分别为 18 nM 和 26 nM。Indomethacin sodium hydrateis 具有抗癌和抗感染活性。Indomethacin sodium hydrateis 可用于癌症、炎症和病毒感染的研究。
研究领域:Immunology/Inflammation | Anti-infection
作用靶点:COX | Bacterial | Influenza Virus | Antibiotic
In Vitro: Indomethacin (Indometacin) sodium hydrateis (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro.
Indomethacin (Indometacin) sodium hydrateis (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2 μM).
In Vivo: Indomethacin (Indometacin) sodium hydrateis (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia.
Indomethacin (Indometacin) sodium hydrateis (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo.
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