MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ganciclovir sodium

CAS No. : 107910-75-8

MCE 国际站：Ganciclovir sodium

产品活性：Ganciclovir (BW 759) sodium 是一种核苷类似物和口服抗病毒活性分子，对 CMV 具有抗病毒活性。Ganciclovir sodium 在体外对疱疹病毒 (herpes group) 和其他一些 DNA 病毒也具有抗病毒活性。Ganciclovir sodium 抑制人类疱疹病毒 (HSV 1 型和 2 型，CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的体外复制。Ganciclovir sodium 对猫 1 型疱疹病毒 (FHV-1) 的 IC₅₀ 为 5.2 μM，可透过大脑屏障。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage

作用靶点：CMV  |  HSV  |  Antibiotic  |  Nucleoside Antimetabolite/Analog

In Vitro: Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median Ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 μM versus 72 μM for acyclovir.
The primary mechanism of Ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase.

In Vivo: Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear.
Ganciclovir (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Anti-Lung Cancer Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Tumorigenesis-Related Compound Library  |  Rare Diseases Drug Library  |  EMA-Approved Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  (1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  2’-dG (iBu)-2’-phosphoramidite  |  Doxorubicin-¹³C,d₃ TFA  |  Antibiotic A-33853  |  Sulbactam-d₂ sodium  |  Peldesine dihydrochloride  |  3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine  |  IBU-DC Phosphoramidite  |  8-Methylguanosine  |  Azlocillin sodium salt  |  2'-Deoxy-8-methylamino-adenosine  |  N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine  |  Toyocamycin  |  7-Ethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine  |  Hispolon  |  SPR206 acetate  |  Doxycycline calcium  |  Staurosporine  |  5’-Deoxy-5’-N-methylaminothymidine  |  N-Acetyl-2′-deoxycytidine  |  Dihydrostreptomycin sulfate  |  5-Carboxymethylaminomethyluridine  |  3-Deoxy-1,2-O-isopropylidene-5-p-toluoyl-a-D-glycero-pent-3-enofuranose  |  3,5-Di-O-benzoyl-2-deoxy-2-fluoro-5-trifluoromethyl-arabinouridine  |  6-Mercaptopurine-¹³C₂,¹⁵N  |  4′,5′-Didehydro-5′-deoxyadenosine  |  2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine  |  2’-Deoxy-2’-fluoro-N1-methyluridine  |  5'-Homocytidine  |  WX-081

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。