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Glimepiride

CAS No. : 93479-97-1

MCE 国际站：Glimepiride

产品活性：Glimepiride (Glimperide) 是中长效的磺酰脲类抗糖尿病化合物，ED₅₀为 182 μg/k。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vivo: Glimepiride (Glimperide) is a new sulfonylurea. After oral administration of Hoe 490 to rabbits, blood glucose was lowered 3.5 times more than after glibenclamide (HB 419) and after intravenous administration, 2.5 times more. Glimepiride (Glimperide) decreased extracellular Aβ40 and Aβ42 levels. glimepiride may serve as a promising drug for the treatment of AD associated with diabetes. Glimepiride (Glimperide) was generally associated with lower risk of hypoglycemia and less weight gain compared to other sulfonylureas. Glimepiride (Glimperide) use may be safer in patients with cardiovascular disease because of its lack of detrimental effects on ischemic preconditioning.

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