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PDGF-BB Protein, Human

MCE 国际站：PDGF-BB Protein, Human

PDGF-BB Protein, Human是血小板衍生生长因子 (PDGF) 中最有效的亚型，能够与 PDGFR 结合，促进不同类型细胞增殖和骨发生，进一步刺激骨折或缺损的骨生成。

Synonyms: rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

Species: Human

Source: E. coli

Biological Activity: 1.The ED₅₀ is <3 ng/mL as measured by murine Balb/c 3T3 cells, corresponding to a specific activity of >3.3 × 10⁵ units/mg.
2.Measured in a cell proliferation assay using BALB/c 3T3 cells. The ED₅₀ for this effect is 5-42 ng/mL.

研究背景：Recombinant Human Platelet-derived Growth Factor-BB is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect. Platelet-derived growth factor-BB (PDGF-BB) is primarily secreted from platelet α-granules and is the most active PDGF isoform in bone and other connective tissue as it can bind to all known PDGF receptors. PDGF-BB plays an important role in bone regeneration by inducing mitogenesis, chemotaxis, extracellular matrix formation, and vascularization. Recombinant Human Platelet-derived Growth Factor-BB (rhPDGF-BB) accelerates tendon healing by improving matrix remodeling, increased collagen synthesis, and increased cell proliferation. Recombinant Human Platelet-derived Growth Factor-BB is also efficacious in a non-ruptured, degenerated, tendinopathy model. Furthermore, Recombinant Human Platelet-derived Growth Factor-BB addresses chronic tendinopathies by inducing proliferation and migration of progenitor cells and tenocytes, which stimulate structural repair of the degenerated tendon.

蛋白编号：P01127 (S82-T190)

基因 ID：5155

产品分类：细胞因子和生长因子  |  血小板源性生长因子及受体  |  血小板源性生长因子  |  PDGF-BB

Categories：Cytokines and Growth Factors  |  PDGFs & PDGFRs  |  PDGF  |  PDGF-BB

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