J Mass Spectrom. 2010 Mar;45(3):252-60. doi: 10.1002/jms.1709. Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform. Kertesz V1, Van Berkel GJ. Author information   Abstract

A fully automated liquid extraction-based surface sampling device utilizing an Advion NanoMate chip-based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This software interface provided the parameter control necessary for the NanoMate robotic pipettor to both form and withdraw a liquid microjunction for sampling from a surface. The system was tested with three types of analytically important sample surface types, viz., spotted sample arrays on a MALDI plate, dried blood spots on paper, and whole-body thin tissue sections from drug dosed mice. The qualitative and quantitative data were consistent with previous studies employing other liquid extraction-based surface sampling techniques.

Published in 2009 by John Wiley & Sons, Ltd.

Automated liquid extraction-based surface sampling

All samples were analyzed using a NanoMate 100 system (Advion BioSciences, Inc. Ithaca, NY, USA) coupled to a 4000 QTRAP ® mass  spectrometer  (MDS  SCIEX,  Concord,  Ontario,  Canada).