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Mental Disorders EpiTect Methyl qPCR Array

精神障碍甲基化PCR芯片
 

ProductSpeciesTechnologyCat. No.Mental Disorders EpiTect Methyl qPCR ArrayHumanDNA MethylationEAHS-601ZMental Disorders EpiTect Methyl qPCR ArrayMouseDNA MethylationEAMM-601ZMental Disorders EpiTect Methyl qPCR ArrayRatDNA MethylationEARN-601Z

The Human Mental Disorders EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes experimentally identified as hypermethylated or hypomethylated in neurodegenerative or psychiatric disorders. Inheritance or accumulation of aberrant genomic DNA methylation epigenetically represses the expression of genes, disrupting normal biological processes. This array includes genes differentially regulated at an epigenetic level in the inborn and acquired mental disorders of Alzheimer’s disease, schizophrenia, depression, bipolar disorder, autism, and alcoholism. Profiling research samples containing genomic DNA from cellular or fresh tissue with this array may help correlate CpG island methylation status with the corresponding biological phenotypes. The results may also help provide further insights into the molecular mechanisms and biological pathways behind these mental disorders. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes involved in mental disorders with this DNA methylation PCR array.
The EpiTect Methyl Signature qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease. Both 96-well and 384-well ( 4 X 96 ) formats are available.
 
精神障碍甲基化PCR芯片用于研究实验已确定在退行性神经或精神疾病中低甲基化或高甲基化的22个基因的启动子甲基化状态。遗传性或积累性因组DNA甲基化异常表观遗传调控抑制基因的表达,扰乱正常的生物过程。这个芯片包含阿尔茨海默氏症、精神分裂症、抑郁症、双相情感障碍、自闭症和酗酒的先天和后天精神疾患中在表观遗传水平差异表达的基因。利用这些芯片分析细胞或新鲜组织基因组DNA样本有助于关联CpG岛甲基化状态与生物表型。结果还可以洞察精神障碍背后的分子机制和生物学通路。利用这个芯片，通过简单的限制性内切酶消化和实时定量PCR，就可以研究分析22个不同精神障碍关键基因的启动子甲基化状态。
 
包括96-孔板和384-孔板( 4 X 96 )。
Alzheimer's Disease: APP, BDNF, DRD2, GABRA2, GAD1, HOXA1, LDLR, SORBS3, TERT, TFAM.
Schizophrenia: AUTS2, BDNF, DRD2, GABRA2, GAD1, GLS2, HOXA1, ISL2, LDLR, LHX5, NR4A2, RELN, RPL39, RPP21, SORBS3.
Bipolar Disorder / Depression: COMT, DRD2, SMS.
Alcoholism:AVP.
Autism:MECP2.