Human Cell Cycle ChIP PCR Array The Human Cell Cycle EpiTect Chip qPCR Array profiles the histone modification status or “histone code” of 84 genes key to cell cycle regulation. Histone modifications regulate chromatin structure, genome integrity and transcriptional activity. Inappropriate increases or decreases in the expression of cell cycle regulators by epigenetic mechanisms contribute to oncogenesis and senescence. For example, histone methylation (H3K9) of the CDKN1A promoter causes transcriptional repression of this gene, leading to uncontrolled cell cycle progression. Epigenetic regulation of cell cycle gene expression also occurs during differentiation and development programs, from multipotent progenitor cells to terminally differentiated non-dividing cells. This array contains genes that positively and negatively regulate the cell cycle, its phase transitions and checkpoints, DNA replication and cell cycle arrest. Using chromatin immunoprecipitation and this real-time PCR Array, you can easily and reliably analyze the histone modification patterns associated with a focused gene panel involved in the cell cycle.
The EpiTect Chip qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
 ProductSpeciesTechnologyCat. No.Cell Cycle EpiTect ChIP qPCR ArrayHumanHistone ModificationsGH-020ACell Cycle EpiTect ChIP qPCR ArrayMouseHistone ModificationsGM-020A    





 

G1 phase and G1/S Transition: ANAPC2, CCND1, CCNE1, CDC34, CDK4, CDK6, CDKN1B (p27KIP1), CDKN2C (p19INK4C), CDKN3, CUL2, CUL3, SKP2. 
S phase and DNA Replication: ABL1, MCM2, MCM3, MCM4, MCM5, PCNA, RPA3, SUMO1, UBA1. 
G2 phase and G2/M Transition: ANAPC2, ANAPC4, DIRAS3, BCCIP, BIRC5, CCNB1, CCNG1, CCNH, CCNT1, CCNT2, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, DDX11, DNM2, GTF2H1, GTSE1, KPNA2, MNAT1, SERTAD1. 
M Phase: BRCA2, CCNB2, CCNF, CDC2, CDC16, CDC20, MRE11A, RAD51. 
Cell Cycle Checkpoint and Cell Cycle Arrest: ATM, ATR, BRCA1, BRCA2, CCNG2, CDC2, CDC34, CDK2, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CDKN2A (p16INK4), CDKN2B (p15INK4b), CDKN2C (p18INK4C), CDKN3, CHEK1, CHEK2, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L1BP, MAD2L2, NBN, RAD1, RAD17, RAD9A, RB1, RBBP8, TP53. 
Regulation of the Cell Cycle: ABL1, ANAPC2, ANAPC4, DIRAS3, ATM, ATR, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCNE1, CCNF, CCNH, CCNT1, CCNT2, CDC16, CDC2, CDC20, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CKS1B, DDX11, E2F4, GADD45A, KNTC1, MKI67, PCNA, RAD9A, RB1, SKP2, TFDP1, TFDP2. 
Negative Regulation of the Cell Cycle: ATM, BAX, BRCA1, CDKN2B (p15INK4b), RBL1, RBL2, TP53.
 
 

 

G1 phase and G1/S Transition: ANAPC2, CCND1, CCNE1, CDC34, CDK4, CDK6, CDKN1B (p27KIP1), CDKN2C (p19INK4C), CDKN3, CUL2, CUL3, SKP2. 
S phase and DNA Replication: ABL1, MCM2, MCM3, MCM4, MCM5, PCNA, RPA3, SUMO1, UBA1. 
G2 phase and G2/M Transition: ANAPC2, ANAPC4, DIRAS3, BCCIP, BIRC5, CCNB1, CCNG1, CCNH, CCNT1, CCNT2, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, DDX11, DNM2, GTF2H1, GTSE1, KPNA2, MNAT1, SERTAD1. 
M Phase: BRCA2, CCNB2, CCNF, CDC2, CDC16, CDC20, MRE11A, RAD51. 
Cell Cycle Checkpoint and Cell Cycle Arrest: ATM, ATR, BRCA1, BRCA2, CCNG2, CDC2, CDC34, CDK2, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CDKN2A (p16INK4), CDKN2B (p15INK4b), CDKN2C (p18INK4C), CDKN3, CHEK1, CHEK2, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L1BP, MAD2L2, NBN, RAD1, RAD17, RAD9A, RB1, RBBP8, TP53. 
Regulation of the Cell Cycle: ABL1, ANAPC2, ANAPC4, DIRAS3, ATM, ATR, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCNE1, CCNF, CCNH, CCNT1, CCNT2, CDC16, CDC2, CDC20, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CKS1B, DDX11, E2F4, GADD45A, KNTC1, MKI67, PCNA, RAD9A, RB1, SKP2, TFDP1, TFDP2. 
Negative Regulation of the Cell Cycle: ATM, BAX, BRCA1, CDKN2B (p15INK4b), RBL1, RBL2, TP53.
 
 

 

G1 phase and G1/S Transition: ANAPC2, CCND1, CCNE1, CDC34, CDK4, CDK6, CDKN1B (p27KIP1), CDKN2C (p19INK4C), CDKN3, CUL2, CUL3, SKP2. 
S phase and DNA Replication: ABL1, MCM2, MCM3, MCM4, MCM5, PCNA, RPA3, SUMO1, UBA1. 
G2 phase and G2/M Transition: ANAPC2, ANAPC4, DIRAS3, BCCIP, BIRC5, CCNB1, CCNG1, CCNH, CCNT1, CCNT2, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, DDX11, DNM2, GTF2H1, GTSE1, KPNA2, MNAT1, SERTAD1. 
M Phase: BRCA2, CCNB2, CCNF, CDC2, CDC16, CDC20, MRE11A, RAD51. 
Cell Cycle Checkpoint and Cell Cycle Arrest: ATM, ATR, BRCA1, BRCA2, CCNG2, CDC2, CDC34, CDK2, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CDKN2A (p16INK4), CDKN2B (p15INK4b), CDKN2C (p18INK4C), CDKN3, CHEK1, CHEK2, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L1BP, MAD2L2, NBN, RAD1, RAD17, RAD9A, RB1, RBBP8, TP53. 
Regulation of the Cell Cycle: ABL1, ANAPC2, ANAPC4, DIRAS3, ATM, ATR, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCNE1, CCNF, CCNH, CCNT1, CCNT2, CDC16, CDC2, CDC20, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CKS1B, DDX11, E2F4, GADD45A, KNTC1, MKI67, PCNA, RAD9A, RB1, SKP2, TFDP1, TFDP2. 
Negative Regulation of the Cell Cycle: ATM, BAX, BRCA1, CDKN2B (p15INK4b), RBL1, RBL2, TP53.
 
G1 phase and G1/S Transition: ANAPC2, CCND1, CCNE1, CDC34, CDK4, CDK6, CDKN1B (p27KIP1), CDKN2C (p19INK4C), CDKN3, CUL2, CUL3, SKP2. S phase and DNA Replication: ABL1, MCM2, MCM3, MCM4, MCM5, PCNA, RPA3, SUMO1, UBA1. 
G2 phase and G2/M Transition: ANAPC2, ANAPC4, DIRAS3, BCCIP, BIRC5, CCNB1, CCNG1, CCNH, CCNT1, CCNT2, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, DDX11, DNM2, GTF2H1, GTSE1, KPNA2, MNAT1, SERTAD1. 
M Phase: BRCA2, CCNB2, CCNF, CDC2, CDC16, CDC20, MRE11A, RAD51. 
Cell Cycle Checkpoint and Cell Cycle Arrest: ATM, ATR, BRCA1, BRCA2, CCNG2, CDC2, CDC34, CDK2, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CDKN2A (p16INK4), CDKN2B (p15INK4b), CDKN2C (p18INK4C), CDKN3, CHEK1, CHEK2, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L1BP, MAD2L2, NBN, RAD1, RAD17, RAD9A, RB1, RBBP8, TP53. 
Regulation of the Cell Cycle: ABL1, ANAPC2, ANAPC4, DIRAS3, ATM, ATR, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCNE1, CCNF, CCNH, CCNT1, CCNT2, CDC16, CDC2, CDC20, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CKS1B, DDX11, E2F4, GADD45A, KNTC1, MKI67, PCNA, RAD9A, RB1, SKP2, TFDP1, TFDP2. 
Negative Regulation of the Cell Cycle: ATM, BAX, BRCA1, CDKN2B (p15INK4b), RBL1, RBL2, TP53.