产品描述
转录因子PCR芯片 Transcription Factors PCR Array
转录因子PCR芯片可以同时检测84关键转录因子的表达情况。这些转录因子可以直接控制基因表达的时间、位置，以及基因表达的程度。这款芯片涵盖了能被各类来源的信号激活的转录因子。这些信号来源包括：细胞因子，趋化因子，生长因子（如：BMP、EGF、EPO、IGF、insulin、PDGF、TGFß、TPO和VEGF），雄激素受体，B-cell受体，G蛋白偶联受体，T细胞受体，Toll样受体，以及各类信号转导通路（如JAK/STAT、JNK和其它的MAP激酶、NFkB、Notch和WNT）。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测转录因子相关基因的表达。
Androgen Receptor Signaling: AR, CTNNB1, RB1. Insulin Signaling: ELK1, FOS, FOXO1, JUN. G-Protein-Coupled Receptor Signaling: CREB1, ELK1, FOS, JUN, NFATC1. Growth Factor Signaling: EGF Signaling: ELK1, FOS, JUN, STAT1, STAT3, STAT5A. IGF-1 Signaling: ELK1, FOS, JUN. PDGF Signaling: ELK1, FOS, JUN, STAT1, STAT3, STAT5A. VEGF Signaling: ARNT, HIF1A, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4. JAK/STAT Signaling: CREBBP, MYC, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. Notch Signaling: CREBBP, HDAC1. TGFß/BMP Signaling: CREBBP, ID1, MYC, SMAD1, SMAD4, SMAD5, SMAD9, SP1. Wnt Signaling: CREBBP, CTNNB1, HNF4A, JUN, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4 (NFAT3), SMAD4, TCF7L2, TP53. Immune Signaling: NF?B Signaling: NFKB1, NR3C1 (GRL), REL, RELA, RELB, STAT1. Toll-like Receptor Signaling: ELK1, FOS, IRF1, JUN, NFKB1, PPARA, RELA, STAT1. T-Cell & B-Cell Receptor Signaling: ELK1, FOS, JUN, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1. Cytokine and Chemokine-mediated Signaling: CEBPA, RELA, STAT3, STAT4, STAT5A, STAT5B. EPO Signaling: ELK1, FOS, JUN, STAT5A. TPO Signaling: FOS, JUN, STAT1, STAT3, STAT5A. MAPK Signaling: Erk1/Erk2 Signaling: ELK1, MYC, STAT3. JNK Signaling: ATF2 (CREB2), ELK1, JUN, MEF2A. p38 Signaling: ATF2 (CREB2), CREB1, ELK1, MAX, MEF2A, MYC, STAT1. Other TFs involved in the MAPK Signaling: ATF4, CEBPA, FOS, JUN, JUND, MEF2C, NFATC2, NFATC4 (NFAT3), NFKB1, SP1, STAT1, TP53. Other Transcription Factors: ATF1, ATF3, CEBPB, CEBPG, DR1, E2F1, E2F6, EGR1, ESR1 (ERa), ETS1, ETS2, FOXA2 (HNF3B), FOXG1, GATA1, GATA2, GATA3, GTF2B, GTF2F1, HAND1, HAND2, HOXA5, HSF1 (TCF5), JUNB, MYB, MYF5, MYOD1, NFYB, PAX6, POU2AF1, PPARG, SP3, TBP, HNF1A, TFAP2A, TGIF1, YY1.
