Human Notch Signaling Pathway DNA Methylation PCR Array: EAHS-611Z The Human Notch Signaling Pathway EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes central to Notch signal transduction. The Notch signaling pathway regulates the expression of genes mediating cell-cell communication and developmental processes. DNA methylation status changes on key regulatory genes during development affect their ability to be induced or repressed by Notch and other signaling pathways. Profiling research samples containing genomic DNA from cellular or fresh tissue with this array may help to correlate CpG island methylation status with biological phenotypes such as developmental stages. This array contains key ligands, cofactors, receptors, downstream signaling effectors, and target genes for Notch signaling. The results may also help provide further insights into the molecular mechanisms and biological pathways behind the role of Notch signaling during cellular communication, differentiation, and development. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes central to Notch signal transduction with this DNA methylation PCR array.
The EpiTect Methyl Signature qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease. Both 96-well and 384-well ( 4 X 96 ) formats are available.
The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC.     

Ligands & Receptors: ADAM17, DLL1, DLL3, JAG1, LFNG, NOTCH1.
Gamma Secretase Complex: NCSTN, PSENEN.
Downstream Signaling: DVL3, NUMBL.
Transcription Factors: RBPJL, SNW1.
Transcriptional Activators / Repressors: CREBBP, CTBP1, HDAC2, KAT2A, MAML1, NCOR2.
Target Genes: CCND1, ERBB2, HES1, NFKB2