Inflammatory Response and Autoimmunity ChIP PCR Array The Human Response and Autoimmunity EpiTect Chip qPCR Array profiles modified histone and nuclear protein binding to the proximal promoter of a panel of genes involved in inflammation and Inflammatory Response and Autoimmunitys. The array contains 96 pairs of qPCR primers targeting the 1-kb region downstream of the transcription start sites (TSS) of 84 biological important genes plus 12 appropriate control regions. The genes represented by this array demonstrate at least differential regulation at the transcriptional level if not also known associations with modified histones. This array includes cytokine, cytokine receptor, transcription factor, and other signaling molecule genes mediating immune cascade reactions during inflammation and Inflammatory Response and Autoimmunitys. Thoroughly researched panels of genes involved in the acute-phase, inflammatory, and humoral immune responses are represented as well. Profiling the histone modifications and nuclear protein binding events at these gene promoters in your immune cell populations will help you correlate these interactions with each gene's known inflammatory role. The results also provide insights into the epigenetic molecular mechanisms and biological pathways behind inflammatory Response and Autoimmunity, especially chronic inflammation. Using Chromatin Immunoprecipitation and this real-time PCR Array, you can easily and reliably analyze the association between your chosen nuclear factors and the promoters for a focused gene panel involved in inflammation.    

Chemokines: C5, CCL1, CCL11, CCL17, CCL19, CCL2, CCL20, CCL21, CCL3, CCL3, CCL4, CCL5, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL5, CXCL6, CXCL9, IL13, IL8.
Chemokine Receptors: CCR3, CCR4, CCR5, CCR6, CCR9, CX3CR1, IL10RB, IL1R1, IL1RN, IL6R, IL8RB.
Cytokine Genes: CD40LG, CSF2, FASLG, IFNA2, IFNG, IL10, IL13, IL15, IL17A, IL17C, IL17F, IL18, IL1A, IL1B, IL1F10, IL1RN, IL2, IL21, IL22, IL3, IL4, IL5, IL6, IL8, IL9, LTA, LTB, MIF, SPP1, TGFB1, TNF.
Cytokine Receptors: CCR3, CCR4, CCR5, CCR6, CXCR4, IFNA2, IL10RA, IL10RB, IL13, IL13RA1, IL5RA, IL8RB, IL9, TNFRSF1B.
Transcription Factors: FOXP3, GATA3, JUN, RELA.
Acute-Phase Response: CEBPB, CRP, IL22, IL6.
Inflammatory Response and Autoimmunity: ABCF1, BCL6, C3, CCL11, CCL17, CCL19, CCL2, CCL21, CCL3, CCL4, CCL5, CCR3, CCR4, CD40, CD40LG, CEBPB, CRP, CXCL1, CXCL10, CXCL5, CXCL6, CXCL9, FOS, IL10, IL10RB, IL18RAP, IL1A, IL1B, IL1F10, IL1R1, IL1RN, IL22, IL8, IL8RB, IL9, LTB4R, NFKB1, PTGS2, TLR4, TMPRSS11D, TNF, TOLLIP.
Humoral Immune Response: C3, CCL2, CCL3, CD40, IL10, IL18, IL1B, IL6, NFKB1