美迪西—结构生物学服务-参数-价格-上海美迪西生物医药有限公司手机站

Molecular Biology/分子生物学
- Plasmid DNA preparation/质粒制备
- Subcloning/亚克隆
- Custom ORF cloning/ORF克隆
- Mutagenesis services/基因突变
- Molecular diagnosis/分子诊断

The E. Coli System/大肠杆菌表达系统
- Protein expression optimization and solubility test/蛋白质表达优化及可溶性表达筛选
- Refolding/蛋白质折叠复性
- Small scale expression and purification/小规模蛋白质表达及纯化
- Scale up expression and purification/大规模蛋白质表达及纯化

The Baculovirus System/昆虫细胞表达系统
- Generation of high titer baculovirus stock (BV stock)/高低度病毒制备
- Expression & optimization in Sf9, Sf21 and Hi5 cell lines/Sf9, Sf21 and Hi5细胞系表达优化
- Pilot protein expression and purification/小规模蛋白质表达及纯化

The Mammalian System/哺乳动物表达系统
- CHO, Vero, BHK, 293 cells etc/CHO, Vero, BHK, HEK293 等多种表达系统
- Adherence and suspension culture/贴壁及悬浮培养
- Transient expression screen/瞬转表达筛选
- Stable cell line generation/稳定细胞系建立

Crystallization & Structural Determination/蛋白质晶体结构测定
- Crystallization condition screening/结晶条件筛选
- Co-crystallization and soaking/蛋白质共结晶及小分子浸泡
- 3-D structural determination /三维结构解析

Computational Biology & Molecular Modeling/计算生物学和分子模型构建
- Structural-Based Drug Design (SBDD)/基于结构的药物设计
  - Target family analysis: using prior knowledge (specificity)/目标族群分析：利用优先知识（特异性）
  - Homology modeling/同源建模
Quantitative structure-activity relationship (QSAR)/定量构效关系
Virtual drug screening/计算机虚拟筛选
- Pharmacophore match for docking-based virtual screen/药物匹配对接的虚拟筛选
- - Hypothesis-driven docking/假设驱动的对接
  - Enhancing results of virtual screens using data mining/提高使用数据挖掘的虚拟筛选的结果
  - De novo drug design/全新药物设计

上海美迪西生物医药有限公司