The determination of pesticide residues in food products is important especially for infants and children, as the quantity of food they ingest per kilogram of body weight is relatively high. Some pesticides are known or suspected endocrine disrupting chemicals (EDCs), so the potential for interference with the function of the naturally occurring hormones can severely impact a growing child, even at low concentrations. The implications of long-term, low-dose exposure through food consumption have led to interest in development of highly sensitive analytical methods that combine rapid sample preparation with hyphenated separation and detection. Most pesticide residue laboratories use some variation of the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction methods. Often the extracted material is analyzed using gas chromatography-tandem mass spectrometry (GC/MS/MS) for the thermally stable, less polar pesticides, or liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis for the less volatile and/or more polar ones. A more recently developed alternative technique involves coupling GC to triple quadrupole ICP-MS (GC-ICP-QQQ), which is able to Determination of pesticides in foods using phosphorus and sulfur detection by GC-ICP-QQQ Application note Authors Jenny Nelson1-3, Helene Hopfer1-2,4, Fabio Silva3 , Steve Wilbur3 , Jianmin Chen3 , Kumi Shiota Ozawa3 and Philip L. Wylie5 1 Department of Viticulture and Enology, University of CaliforniaDavis, Davis CA, USA 2 Food Safety and Measurement Facility, University of CaliforniaDavis, Davis CA, USA 3 Agilent Technologies, Inc., Santa Clara CA, USA 4 HM Clause, Davis CA, USA 5 Agilent Technologies, Inc., Wilmington DE, USA Food testing 2 determine pesticides by measuring the heteroatoms P and S (also Cl and Br) contained in most pesticides. GC-ICP-QQQ offers very good selectivity and specificity, and sensitivity that can be greater than the established methods. The method described in this work can be applied to other compounds such as organophosphorus chemical warfare agents, brominated flame retardants, polymer additives and trace sulfur compounds in flavors and fragrances.