前言：

　　The natural opiates morphine and codeine are widely prescribed drugs for their analgesic, antitussive and antidiarrheal effects. However, they are also widely abused for their psychoactive effects and are often diverted from lawful prescriptions to unlawful recreational use. Simple, robust and precise analytical methods are needed to quantify these compounds in biological matrices for forensic purposes.

仪器：

Thermo Scientific TSQ Quantum mass spectrometer

结论：

　　A robust method with simple and easy sample preparation was developed for forensic toxicology laboratories. The data window and total run time make this method amenable to multiplexing with the Thermo Scientific Transcend system. Multiplexing with the Transcend™ LX-2 LC system would result in a run time of 2.5 minutes per sample. With an LX-4 LC system, the run time could be further reduced to 1.53 minutes per sample.